Tuberculosis can be diagnosed by analysis of exhalation before the symptoms manifest themselves
The authors of the work suggested a way to simplify collection of 'Koch's bacillus', as the bacteria is also called, from the lungs and making it less traumatic for patients. To achieve this, they tried to collect bacteria from air, what patients exhaled, with modified Petryanov filters. It turned out that there are no microbes and their DNA in the exhaled microdroplets of the pulmonary fluid, but there are immunoglobulins A, and among them antibodies that are produced only if Mycobacterium tuberculosis is present in the body.
Immunoassay used in the procedure takes just a few minutes thanks to a number of technical innovations developed by the authors. It allows to detect tuberculosis at the early stages, when the symptoms characteristic of the disease have not yet developed.