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Russian doctors proposed to introduce stem cells into the pelvis

Members of the National Medical Research Centre of Hematology of the Ministry of Health of the Russian Federation have found a way to start hemopoiesis in patients who have not benefited from transplantation of hematopoietic stem cells (HSC). They proposed to introduce multipotent mesenchymal stromal cells (MMSC) into the spongy substance of the ilium along with the source of HSC — donor bone marrow. A scientific article is published in the journal Stem Cells International.
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Russian physicians suggested using MMSC to increase the percentage of successful bone marrow transplant operations. MMSC is one of the types of stem cells that participate in the formation of hematopoietic stem cells, and their main source is also the red bone marrow. It has been tried previously to introduce multipotent mesenchymal stromal cells intravenously together with HSC in an attempt to increase the likelihood of hematopoiesis recovery, but such operations were unsuccessful.

The authors of the work introduced MMSC directly into the red bone marrow of eight patients, who had not had hemopoietic function restored within a month after a HSC transplantation. But this time six out of eight patients had the hemopoietic function recovered within a month.

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