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Cell receptors know more than two words

Vladimir Katanayev, member of the School of Biomedicine at the Far Eastern Federal University (FEFU), and his colleagues from Switzerland determined the options for transmitting information by G-protein coupled receptors (GPCR). Their number turned out to be higher than the previous estimates. To determine it, scientists experimented directly on cell cultures and they also used computer modelling. A scientific article was published in the journal Nature Communications.
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Scientists have found that receptors coupled with G-proteins (GPCR) react to several different concentrations of the signal substance. It was previously believed that receptors can only react in «yes/no» way only — i.e. either by «sensing» the presence of a signal substance, regardless of its concentration outside the cell or by not «feeling» the signal from outside.

The information obtained will be especially important for drug developers. A lot of potential and existing drugs against a variety of diseases affects GPCR. To make this effect actually effective, it is necessary to understand the principle on which G-protein coupled receptors operate.

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