Cell receptors know more than two words
Scientists have found that receptors coupled with G-proteins (GPCR) react to several different concentrations of the signal substance. It was previously believed that receptors can only react in «yes/no» way only — i.e. either by «sensing» the presence of a signal substance, regardless of its concentration outside the cell or by not «feeling» the signal from outside.
The information obtained will be especially important for drug developers. A lot of potential and existing drugs against a variety of diseases affects GPCR. To make this effect actually effective, it is necessary to understand the principle on which G-protein coupled receptors operate.