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«Pathogen» of Alzheimer’s disease can blind for a month

Malaysian researchers, along with Igor Iyezhitsa, member of Volgograd State Medical University (VolgGMU), have found that a fragment of beta-amyloid peptide, which consists of the first forty amino acids of beta-amyloid precursor protein (APP), when introduced into the vitreous (part of the eye between the lens and the retina) causes degeneration of the retina and optic nerve in rats. However, the effect is temporary, and 30 days after the injection the state of the visual system of animals begins to improve. The scientific article is published in the International Journal of Neuroscience.
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The results of the study on rats showed that the fragment of the beta-amyloid precursor, Aβ40, considered to be a non-pathogenic compound, adversely affects the state of the visual system — at least the part that directly perceives visual information and sends it to the brain. Thus, it makes sense to study the effects exerted by this peptide on the structure of the eye. The authors of the study plan to use the data they had obtained to develop models for studying the effects of Aβ40 on the retina in glaucoma and macular degeneration.

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