Nanoparticles with thymus hormone saved mice from chronic inflammation
Members of the Institute of Cell Biophysics of the Russian Academy of Sciences (Pushchino) have learned how thymulin — the hormone of the thymus gland — affects the activity of various types of cells in the immune system of mice with chronic inflammation. It turned out that thymulin, in both free state and being bound to nanoparticles of poly butyl cyanoacrylate, reduces the number of cells dying by apoptosis in such rodents, as well as intensity of fever and formation of pro-inflammatory cytokines. The scientific article is published in the journal PLoS ONE.
The scientists injected laboratory mice with substances that cause inflammation. Some animals were administered thymulin, in a free form or as being attached to poly butyl cyanoacrylate nanoparticles. It turned out that in those mice that received thymulin the inflammation was weaker, less lymphocytes were lost, and the number of cells in the spleen did not decrease.
This means that thymulin reduces the intensity of inflammation and supports the immune system.
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