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Protein which kills one type of cells promotes fast migration of other cells

Researchers from the Karolinska Institute (Sweden) and M.V. Lomonosov Moscow State University guided by Boris Zhivotovsky have found out that the protein caspase-2 accelerates the migration of cells of specific types. This discovery could be applied for promoting the process of wound healing. The research article was published in the journal Biochemical and Biophysical Research Communication.
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Caspase-2 is a protein which evokes cells death. The researchers have discovered that upon interaction of caspase-2 with other protein, FAN, the process of movement of cells to the spot of damage is accelerated, implying that the wound healing undergoes faster. Another discovered effect is the lowering the rate of formation of metastasis by cancer tumors upon retardation of the interaction of these two proteins.

Theoretically, by blocking the work of complex of caspase-2 and FAN, one could slow down the formation of metastasis. If, in contrast, the complex is activated, one could speed up the wound healing. However, additional studies are required to provide evidence that the changes in the activity of these two proteins do not harm other cells.

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