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Russian biochemists have found the cause of the ineffectiveness of the vaccine against influenza

Researchers at the Institute of Bioorganic Chemistry (IBC) of the Russian Academy of Sciences have shown that different versions of the vaccine against seasonal influenza viruses do not actually increase the number of different types of T-cell receptors (TCR), and therefore do not increase the chance of recognising influenza viruses by the body’s immune system. This largely explains why vaccinations against this disease are so ineffective. A scientific article is published in the journal Vaccine. The work was supported by a grant from the Russian Science Foundation (RSF).
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The results of the experiment led the authors to the conclusion that the standard vaccine against influenza practically does not enhance the ability of the human immune system to cope with the causative agent of the disease, since it does not significantly change the TCR repertoire. However, it is possible that each vaccine still leaves behind a «memory» of the antigens encountered. But since the composition of proteins on the surface of influenza viruses changes rapidly due to frequent mutations in the coding genes, information about them almost immediately becomes obsolete and therefore useless for the immune system.

The authors of the article now plan to conduct a study on a larger number of volunteers in order to verify the results obtained.

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