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Russian scientists began work on correction of gene mutations in patients with cystic fibrosis

Experts at the Research Centre of Medical Genetics of the Ministry of Science and Higher Education of the Russian Federation began to conduct experiments with stem cells of patients suffering from cystic fibrosis (aka mucoviscidosis), Svetlana Smirnikhina, the Acting Head of the Laboratory of Mutagenesis at the RCMG, informed.
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«We have obtained skin epithelial cells of patients over 18 years of age; these are patients with the most common among the most severe mutations,» Smirnikhina said. She farther explained that scientists correct mutations in them with the help of special methods of reprogramming of cells. The experiments are carried out using modifications developed in the laboratory of the Russian centre.

Smirnikhina added that there is no effective and affordable pathogenetic treatment aimed at blocking the development of disease mechanisms. «Life expectancy of patients with severe genetic mutations often does not exceed 25 years,» she noted.

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